Molecular mechanisms of nephroprotection by SGLT2 inhibitors: interaction between SIRT1 and hypoxia signaling in diabetic nephropathy
Italian Ministry of Education, University and Research
Deadline
7 November 2026
Description
Offer Description: This project aims to investigate the molecular mechanisms underlying the nephroprotective effects of SGLT2 inhibition, with a focus on the role of the SIRT1/HIF-1α/HIF-2α signaling axis in diabetic nephropathy. The study will explore how empagliflozin (EMPA) modulates the balance between HIF-1α and HIF-2α through SIRT1 activation and how these pathways influence cellular adaptation to metabolic and hypoxic stress. Additional Information: Eligibility criteria Eligible destination country/ies for fellows: Italy Eligibility of fellows: country/ies of residence: EUROPE Eligibility of fellows: nationality/ies: EUROPE Additional comments Contact email: [email protected] Contact phone: 0649697738 Annual budget: 22.500 Frequency of calls: 12 mesi International mobility required: no Website for additional job details https://trasparenza.uniroma1.it/page/5/details/36755/bando-idr-12026_dmcm
Sectors
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