Assistant Professorship (all genders) - Tenure Track

Description

Offer Description: "Protein Engineering (CoE CircBioeng)“ - Assistant Professorship (all genders) - Tenure Track TU Wien is Austria's largest institution of research and higher education in the fields of technology and natural sciences. With over 26,000 students and more than 4000 scientists, research, teaching, and learning dedicated to the advancement of science and technology have been conducted here for more than 200 years, guided by the motto "Technology for People". As a driver of innovation, TU Wien fosters close collaboration with business and industry and contributes to the prosperity of society. At the Institute of Applied Synthetic Chemistry , in the Research Group for Bioorganic Synthetic Chemistry TU Wien is offering the following tenure track position limited for 6 years for 40 hours/week. Expected start: immediately. The candidate and TU Wien can agree upon a tenure evaluation, which when positive, opens the possibility to change the position to Associate Professor with an unlimited contract. This position at the Institute of Applied Synthetic Chemistry, Research Division of Organic and Biological Chemistry, Research Group of Bioorganic Synthetic Chemistry (163-03-4) at TU Wien, and the Institute of Process Engineering, Environmental Engineering and Technical Biosciences, Research Division Biochemical Technology, Research Group Synthetic Biology and Molecular Biotechnology (166-05-1), is to be filled as a dual affiliation. The career position in Protein Engineering is intended to strengthen the primary research areas of “Sustainability, Energy, Environment” and “Bioscience Technologies” at TU Wien in line with the Faculty of Engineering Chemistry’s development plan, with a focus here on protein engineering technologies for application in synthesis and biosynthesis. Furthermore, through collaboration with existing research activities at TU Wien, as well as with other universities and research institutions, the aim is to create and strengthen an interdisciplinary scientific environment with a special focus on the Cluster of Excellence – Circular Bioengineering. Tasks: Research: The successful candidate is expected to establish an innovative research profile at the interface of chemistry and biology. Core responsibilities include: New-to-Nature" Reactivities: Establishing a research program focused on the systematic construction of abiological functions within protein scaffolds (e.g., carbene transfer, unnatural cross-couplings, photoreactions, or non-canonical C-H functionalizations) Computational De Novo Protein Design: Integrating cutting-edge AI architectures (such as AlphaFold 3, RFdiffusion, ProteinMPNN) alongside physics-based methods and mechanistic QM/MM simulations to conceptualize novel biocatalysts Ultra-High-Throughput Screening: Setting up microfluidic systems—specifically Fluorescence-Activated Droplet Sorting (FADS)—for the efficient phenotypic characterization and validation of massive enzyme libraries (>10^7 variants) Data-Driven Workflows: Closing the "Design-Build-Test-Learn" cycle by feeding experimental screening data back into computational models via active learning approaches to continuously optimize predictive power Teaching: In addition to research, the duties of an Assistant Professorship at TU Wien include teaching (in German and English) in Bachelor’s, Master’s and PhD programs, as well as involvement in the management of the institute and the faculty. The main task is to impart the necessary knowledge and methods in the field of protein engineering and related bioinformatics methods. Courses in the Bachelor’s program in Technical Chemistry and the Master’s program in Technical Chemistry are to be expanded or newly established accordingly. Your profile: A completed doctoral or PhD degree relevant to the position from a domestic or equivalent foreign university or research institution, or the completion of an equivalent scientific qualification International post-doctoral experience at

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Source: euraxess.ec.europa.eu