Synthesis and characterization of fluourescent sigma-1 receptor ligands aimed at the Preclinical validation of a novel drug for treating Wolfram syndrome and Type 2A Charcot-Marie-Tooth disease

Ente: Italian Ministry of Education, University and Research

Scadenza: 2026-05-15

Paese: IT

Descrizione

MAMs are intracellular hotspots for: Ca2+ signaling, redox regulation, lipid exchange, mitochondrial quality control and unfolded protein response pathway. They are altered in conditions such as Wolfram syndrome (WS) or Charcot-Marie-Tooth disease Type 2 disease (CMT2A) that cause severe impairments...

Settori: Chemistry

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