[R21] MESH1 Regulates RNA Sensing Through Nucleotide Metabolism
Ente: National Institute of Allergy and Infectious Diseases
Scadenza: 2028-04-30
Importo max: $237,831
Paese: US
Descrizione
Project Abstract
Proper recognition and disposal of aberrant RNA is essential for maintaining immune tolerance while
enabling appropriate antiviral defense. This process is tightly regulated by RNA decay enzymes such as the
5′→3′ exonuclease XRN1, whose activity prevents the accumulation of immunos
Settori: National Institute of Allergy and Infectious Diseases
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