[K01] Optimization and Pilot Testing of a Cognitive Behavioral based Physical Therapy Intervention to Address Falls in People with Multiple Sclerosis
Ente: Eunice Kennedy Shriver National Institute of Child Health and Human Development
Scadenza: 2031-06-30
Importo max: 135.540 EUR
Paese: US
Descrizione
PROJECT SUMMARY/ABSTRACT
This five-year plan for a K01 Mentored Research Scientist Development Award will equip Dr. Libak Abou with
the essential knowledge and skills to help launch his career as an independent researcher specializing in the
development of evidence-based behavioral interventions to address fall-related problems in persons with
neurological conditions. Career Development and Training Activities: A carefully drafted career development
plan will build on Dr. Abou’s expertise in observational studies on fall risk and allow for an expansion of his
skillset as an interventionalist. The structure established by well-defined training goals will ensure his career
development and facilitate his transition to independence. The training goals are: 1) to develop proficiency in
qualitative research methods; 2) to acquire expertise in developing multidisciplinary behavioral intervention
programs; 3) to acquire expertise in conducting clinical trials in neurorehabilitation; and 4) to develop grant
writing skills and successfully submit an R01 application to the National Institutes of Health (NIH). Dr. Abou will
receive mentorship from experts in their respective fields (Drs. Kratz, Archer, Braley, Fritz, and Kidwell) and
take full advantage of the strong institutional support and environment at the University of Michigan Medical
School. Research Plan: Falling is a common problem that affects more than 50% of persons with multiple
sclerosis (MS) and may result in physical injuries, fear of falling, reduced functional independence, poor quality
of life, hospitalizations, and in some cases, fatalities. Consequently, falls place a substantial economic and
taskforce burden on families, healthcare systems, and society. Testing of single modality fall prevention
interventions (e.g., physical therapy for balance) has grown over the past decades; however, recent evidence
underscores the critical need for multidisciplinary interventions to effectively address the diverse factors that
contribute to falls in MS. We propose to optimize an existing Cognitive Behavioral based Physical Therapy
(CBPT), provided by Dr. Archer (co-mentor), to design a fall prevention program that is feasible and acceptable
to address falls-related problems and increase self-efficacy in people with MS. With support and guidance from
his mentors, Dr. Abou will use qualitative methods to gather input from people with MS and healthcare
providers to guide the optimization and refinement of CBPT-Falls program (Aim 1). The qualitative methods
include iterative focus groups for program optimization and refinement, and one-on-one post-intervention
interviews to guide final steps to further refine the program. He will examine the feasibility and acceptability of
CBPT-Falls program by conducting a randomized pilot trial, using a structured PT program as the comparator
(Aim 2); and examine changes over time within treatment groups (Aim 3). Toward the end of this award, Dr.
Abou will submit an
Istituzione: UNIVERSITY OF MICHIGAN AT ANN ARBOR
PI: Libak Abou
Progetto: 1K01HD121935-01
Settori: Eunice Kennedy Shriver National Institute of Child Health and Human Development
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