[T32] Biomedical Research Training in Drug Abuse
Ente: National Institute on Drug Abuse
Scadenza: 2027-06-30
Importo max: 399.402 EUR
Paese: US
Descrizione
Addictions are heritable, polygenic and multifactorial disorders that pose
substantial burden to persons and communities. A biomedical approach to
substance use and addictions, encompassing genetics, neuroscience,
neuroimaging, pharmacology, statistics, biology, informatics and
psychiatry/psychology, along with access to multi-modal data, provides a strong
foundation upon which translational studies aimed at understanding the
neurobiological underpinnings of drug use and misuse are built. This competing
continuation requests another 5 years (years 31-35) of support for 6 postdoctoral
training slots that will provide research training and career development to 3 MDs
and 3 PhDs pursuing postdoctoral research with 27 preceptors across 7
departments (Psychiatry, Anesthesiology, Genetics, Neuroscience, Neurology,
Psychological & Brain Sciences, Biomedical Engineering). The fellowship will
typically encompass a 3-year period for MDs, and a 2-3 year period for PhDs,
depending on the scope of the project. Co-led by Drs. Agrawal and Moron-
Concepcion (with complementary expertise in human and animal neurobiology of
addictions), the Biomedical Research Training in Drug Abuse (BRTD) is the only
T32 which offers biomedical addictions training, with an emphasis on neurobiology,
at Washington University in St. Louis (WUSTL), which is home to 20 additional
postdoctoral institutional training grants. BRTD has a long history of recruiting
highly qualified trainees (1-2 first-authored publications at entry) and securing their
continued academic success. Prior trainees are now tenured faculty members at
WUSTL and elsewhere, science officers for pharmaceutical or biomedical
entrepreneurial companies, and are themselves mentoring the next cohort of
scientists. The 27 preceptors are NIH-funded investigators with a history of
mentorship in addiction-related biomedical research. The trainees devote 70% of
their effort towards mentored research. The remaining effort is devoted to didactics
(coursework, workshops and seminars) that advance the trainees’ breadth of
knowledge and provide new skills (e.g., programming, bioinformatics, data mining)
that keep apace of accelerating big data and computational approaches. In
addition, trainees undertake career development activities in science
communication, and NIH PI-ship, as well as required instruction in Responsible
Conduct of Research (including content specific to addiction) and Reproducibility
in Science. Recognizing that trainees may choose different career trajectories,
they may also engage in grant writing and mock NIH review, teaching, public
speaking or entrepreneurship training. This renewal maintains our strong
emphasis on neurobiology, while adding in novel scientific components (greater
emphasis on multi-modal research, e.g., genetics and human neuroimaging,
neuro-pharmacology and genetics) as well as a robust career development
program that rounds out scientific training. Preceptors with new expertise
(including
Istituzione: WASHINGTON UNIVERSITY
PI: ARPANA AGRAWAL, Jose A Moron-Concepcion
Progetto: 5T32DA007261-35
Settori: National Institute on Drug Abuse
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