[K23] Gray matter microstructure, a sleep-related marker of preclincal Alzheimer's disease
Ente: National Institute on Aging
Scadenza: 2031-04-30
Importo max: 145.706 EUR
Paese: US
Descrizione
PROJECT SUMMARY (ABSTRACT)
This project is a Mentored Patient-Oriented Research Career Development (K23) Award with both research
and career-development training components. The Candidate, a clinical sleep neurologist, has the overarching
career goal of (1) identifying mechanistic markers that are essential to preclinical Alzheimer’s disease
pathogenesis, and (2) determining how sleep physiology contributes to mechanistic markers of Alzheimer’s
disease pathogenesis.
Training provided via this K23 project has been thoughtfully designed to help the Candidate develop into an
independent clinical scientist. The training framework includes mentorship, structured coursework, mentored
research, and a robust team of expert advisors that will fill vital gaps in his scientific education and guide his
professional development. Training will cover the areas of clinical and translational science, Alzheimer’s disease
pathology, the implementation of amyloid/tau/neurodegeneration markers in research, and the implementation
of sleep actigraphy and electroencephalography (EEG) in Alzheimer’s disease research.
Research Specific Aims (1 and 2) proposed in this K23 project will leverage HCHS/SOL to test the
hypotheses that (1) lower brain gray matter microstructure integrity is a marker of preclinical Alzheimer’s disease;
and (2) gray matter microstructure mediates a relationship between modifiable sleep patterns and preclinical
Alzheimer's disease progression in adults. This K23 project will also pilot in-home portable forehead EEG
(Specific Aim 3) as a more ecologically valid alternative to gold-standard in-lab polysomnography (PSG) for
measuring sleep physiology.
The training and research within this K23 will position the Candidate to submit an NIH Research Project
(R01) Grant application that implements in-home portable EEG in a subsequent large scale observational study.
As sleep physiology is plausibly the mechanistic underpinning that mediates the relationship between sleep
patterns and preclinical Alzheimer’s disease progression, the implementation of portable EEG in a subsequent
longitudinal observational study of adults may decipher the specific features of sleep physiology that contribute
to gray matter microstructure decline and Alzheimer’s disease risk. As sleep behaviors are highly modifiable and
influenced by culture, this K23 (and subsequent R01) project may help uncover specific sleep physiology targets
for personalized interventions that help preserve gray matter microstructure and prevent Alzheimer’s disease in
all people.
Istituzione: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
PI: Christian Agudelo
Progetto: 1K23AG097998-01
Settori: National Institute on Aging
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