[R01] Optimizing PepTAC structure and amphiphilicity for enhanced target protein degradation
Ente: National Institute of General Medical Sciences
Scadenza: 2028-05-31
Importo max: $321,106
Paese: US
Descrizione
Project Summary
This study seeks to advance heterobifunctional degraders that induce targeted protein degradation through
the ubiquitin proteasome pathway. Typically, molecular degraders involve a ligand that recruits an E3
ubiquitin ligase and another that targets a protein of interest (POI), formi
Settori: National Institute of General Medical Sciences
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