[R01] Unraveling the spectrum of intrabacterial amide hydrolysis to develop new classes of pyrazinoic acid prodrugs against pyrazinamide resistant Mycobacterium tuberculosis
Ente: National Institute of Allergy and Infectious Diseases
Scadenza: 2030-05-31
Importo max: $792,528
Paese: US
Descrizione
ABSTRACT
Mycobacterium tuberculosis (Mtb) infection is a global health pandemic claiming 1.5 million lives each
year. Current tuberculosis (TB) therapies are challenged by drug resistance, characterized by mutations that
render approved drugs increasingly less effective. PZA is a critical component
Settori: National Institute of Allergy and Infectious Diseases
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