[F31] Dopaminergic modulation of NMDA receptor signaling in the Nucleus Accumbens
Ente: National Institute on Drug Abuse
Scadenza: 2028-07-31
Importo max: 41.846 EUR
Paese: US
Descrizione
Project Summary
Alterations in both dopamine (DA) and glutamate signaling in the Nucleus Accumbens (NAc) are thought to play
a key role in substance use disorders and addiction. DA regulates NAc circuit activity by modulating glutamatergic
transmission and receptor activity, however, the precise mechanisms remain unclear. Synaptic plasticity and
regulation of intracellular excitability is primarily attributed to the functions of glutamatergic NMDA recept ors
(NMDARs). How dopamine receptors regulate NMDAR activity and how this differs between synaptic
connections in accumbal circuitry remain important questions. This proposal will utilize ex vivo slice
electrophysiology in combination with optogenetics and iontophoresis in transgenic mouse lines to investigate
the synapse specificity and intracellular signaling mechanisms underlying DA receptor regulation of NMDAR
current in both D1 and D2 type dopamine receptors. Understanding the synergistic role of D1 and D2 receptor
signaling in regulating glutamate transmission and receptor activity in the NAc is a critical step in the investigation
of both motivation and the dysfunctions that arise in this system after exposure to drugs of abuse.
Istituzione: UNIVERSITY OF COLORADO DENVER
PI: Joy Adler
Progetto: 5F31DA064363-02
Settori: National Institute on Drug Abuse
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