[R21] Time-Efficient Inspiratory Muscle Strength Training for Reducing Sympathetic Activity and Improving Sleep in Midlife Women
Ente: National Institute on Aging
Scadenza: 2028-05-31
Importo max: 439.258 EUR
Paese: US
Descrizione
PROJECT SUMMARY/ABSTRACT
Vasomotor symptoms (hot flashes) associated with menopause consist of rapid and intense sweating, peripheral
vasodilation, and an exaggerated feeling of internal heat. Over 70% of women experience hot flashes at some
point during menopause, which significantly impacts day to day life. Furthermore, hot flash frequency is related
to increased risk of hypertension, cardiovascular disease (CVD), sleep, and mood disorders--even when
controlling for traditional cardiovascular disease risk factors (obesity, hypertension, lipids, etc.). For the purposes
of this application, we will define neurovascular function as a concept that encompasses sympathetic outflow,
the responses of blood vessels to neurotransmitters released by the sympathetic nerves and the intrinsic
properties of the vascular endothelium and smooth muscle. In this context, neurovascular function is critically
important to women’s health and aging. Neurovascular function, including elevated sympathetic control of blood
pressure, has been implicated the positive relationship between hot flashes and cardiovascular disease. Further,
nocturnal awakenings during hot flashes are associated with increases in sympathetic activity. As such, the
overall goal of this application is to assess the impact of a high-resistance inspiratory strength muscle on
sympathetic nerve activity and sleep in postmenopausal females with hot flashes. Aim 1 will determine if 6 weeks
of high-resistance inspiratory muscle strength training reduces sympathetic nerve activity in postmenopausal
females with hot flashes. Aim 2 will establish whether 6 weeks of high-resistance inspiratory muscle strength
training will improve sleep through reductions in nocturnal awakenings due to reduced hot flash frequency in
postmenopausal females with hot flashes. Importantly, this work will provide objective mechanistic evaluation of
autonomic and neurovascular function in midlife women including those undergoing menopause. Understanding
how the neurovascular physiology of women relates to hot flashes will inform hypertension and cardiovascular
disease (CVD) treatment and prevention options, as the presence of hot flashes are a CVD risk factor beyond
traditional CVD risk factors and as such, is likely to be an important determinant for a woman’s health. Thus,
these studies will begin working toward the Applicant’s long-term goal of developing interventions to reduce the
incidence of cardiovascular disease in women with hot flashes. Finally, this work will provide pilot data that
complement the Applicant’s intellectual and technical skills for future work to improve cardiovascular health in
women with menopausal hot flashes.
Istituzione: MAYO CLINIC ROCHESTER
PI: Sarah Elizabeth Baker
Progetto: 1R21AG101515-01
Settori: National Institute on Aging
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