[R01] Novel tools for measuring typhoid vaccine impact
Ente: National Institute of Allergy and Infectious Diseases
Scadenza: 2029-03-31
Importo max: 641.757 EUR
Paese: US
Descrizione
Project Summary
Typhoid fever is a leading cause of invasive bacterial illness and death worldwide. It impacts travelers from the United States as well as military and diplomatic personnel stationed overseas. Highly antimicrobial-resistant strains of Salmonella Typhi have been emerging and spreading internationally and intercontinentally, including to the United States, posing the risk of rising morbidity among reduced effectiveness of therapy. New typhoid conjugate vaccines have demonstrated a high level of effectiveness and are recommended by the WHO; however, many countries lack data on typhoid incidence, as the only reliable tool for typhoid diagnosis—blood culture—is not widely available in many resource-constrained settings where typhoid risk may be greatest. To address these gaps, we propose to leverage a large, cluster-randomized trial of a typhoid conjugate vaccine being performed in Vellore, India, to test three emerging tools to measure community burden of typhoid: 1) seroepidemiological models, utilizing recently characterized seroresponses to S. Typhi antigens; 2) detection of S. Typhi-specific bacteriophages in wastewater, using low-cost assays; 3) phylodynamic methods that track measures of transmission intensity. This project will provide rigorous testing of multiple innovative methods amid uniquely intensive clinical surveillance in a vaccine trial. Overall, this project will address a critical need for public health tools to make typhoid surveillance scalable in resource-constrained settings, to inform vaccine introductions and monitor their impact.
Istituzione: STANFORD UNIVERSITY
PI: Jason Randolph Andrews, Richelle C Charles, Jacob John
Progetto: 5R01AI181283-03
Settori: National Institute of Allergy and Infectious Diseases
Vai al bando originale
Registrati gratis su Bandolo per trovare bandi compatibili con la tua azienda.