[R01] Mechanisms and Functional Roles of PARP1 Hyperactivation in Cancer
Ente: National Cancer Institute
Scadenza: 2031-05-31
Importo max: $639,707
Paese: US
Descrizione
PROJECT SUMMARY
Genomic integrity is constantly challenged by endogenous and exogenous factors such as replication stress,
APOBEC enzymes, UV radiation, and chemical agents that induce DNA damage. The DNA Damage Response
(DDR) serves as a critical safeguard, detecting lesions and activating repair p
Settori: National Cancer Institute
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