[F31] Network Modeling of Dietary Effect on Host and Microbial Metabolism
Ente: National Institute of Diabetes and Digestive and Kidney Diseases
Scadenza: 2028-05-20
Importo max: 50.114 EUR
Paese: US
Descrizione
Project Summary
The human gut microbiome plays a critical role in host health, influencing complex diseases such as obesity,
type 2 diabetes, Alzheimer’s, and Parkinson’s disease. A key mediator of this relationship is microbial
metabolism of compounds present in the diet. Understanding the interplay among diet, microbes, and the host
is crucial to advancing knowledge of human health and disease. Dietary compounds can be metabolized by gut
microbes and the host, producing metabolites that impact health outcomes. For example, microbial-host co-
metabolism of choline from red meat into trimethylamine-N-oxide (TMAO) increases heart disease risk, while
other microbe-host co-metabolic pathways, such as those involving polyphenols or essential amino acids, have
protective effects. Despite this, current computational tools lack a unified approach to directly link dietary
compounds, microbial enzymatic functions, and host metabolism. This proposal seeks to address this gap by
developing a networks-based framework (nodes and edges) to integrate genomic, microbiome, metabolomic,
and dietary data. Using experimental datasets from individuals with diverse dietary patterns and disease states,
including a cohort of people living with HIV (PLWH) in Zimbabwe and a large inflammatory bowel disease (IBD)
dataset, this work will systematically connect diet-originating compounds with microbial and host enzymes. This
approach will enhance the ability to detect diet-microbe-host interactions, facilitating the exploration of co-
metabolism in diverse health contexts. Leveraging databases such as the Kyoto Encyclopedia of Genes and
Genomes (KEGG) and FooDB, the overarching objective of this study is to develop a computational framework
to analyze diet-microbe-host interactions at the compound-enzyme level. The findings will provide a scalable,
queryable framework applicable to any related biological experiment, offering new tools for studying the impacts
of diet on health through gut microbiome activity. Ultimately, this work will advance understanding of diet-
microbe-host interactions and their contributions to disease mechanisms, guiding future research and
therapeutic development.
Istituzione: UNIVERSITY OF COLORADO DENVER
PI: Angela Sofia Burkhart Colorado
Progetto: 1F31DK145063-01
Settori: National Institute of Diabetes and Digestive and Kidney Diseases
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