[Research Grant] EBI Metagenomics Portal - Towards a better understanding of community metabolism
Ente: Biotechnology and Biological Sciences Research Council
Scadenza: 2018-05-09
Paese: GB
Descrizione
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EBI-MP is a global portal for the metagenomics research community. Offering data submission, archiving and sharing functions, community standards-compliant curation, and functional and taxonomic diversity analyses, the service has attracted a growing user-base of UK, European and global researchers.
We intend to improve the pipeline infrastructure to offer analysis provenance by modularising pipeline components, defining a dependency tree between modules, and module versioning. Subsequently, we will perform updates to reference databases and analysis software, and make results reanalysis with the updated pipeline actionable for our users. We will improve the range of taxonomic annotations provided by the resource, moving beyond 16S rRNA-based analyses. We will also investigate the application of the UniPept approach to taxonomic classification for metagenomic datasets. We will add pathway information to the functional annotation provided by EBI-MP, using the latest version of InterProScan to provide KEGG, MetaCyc and UniPathway links, and develop a tool to visualise the catalytic potential of a sample, highlighting reactions where there is support for the existence of constituent proteins.
We will implement CRAM compressed sequence data formats within the system to increase the speed of upload of data to EBI-MP and to facilitate internal processing and storage. We will also design and build data discovery tools that provide a full range of search functions across the sample
Settori: Sch of Engineering
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