Spinal microcircuit resilience in Amyotrophic Lateral Sclerosis (ALS): mechanisms, translational insights and therapeutic windows

Ente: WT

Scadenza: 2034-03-31

Importo max: 2.753.860 €

Paese: EU

Descrizione

Neural circuits exhibit remarkable resilience in early-stages of neurological disease to maintain near-normal behaviour. In amyotrophic lateral sclerosis (ALS) more than 50% of motoneurons die before muscle weakness is detected. Human studies have shown deterioration of spinal pathways in late-sympt

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