[F31] Well-being in the Face of Adversity: A comparison of the role of positive psychosocial factors on health outcomes in Black women with vs. without Systemic Lupus Erythematosus
Ente: National Institute of Arthritis and Musculoskeletal and Skin Diseases
Scadenza: 2028-06-30
Importo max: 50.114 EUR
Paese: US
Descrizione
PROJECT SUMMARY/ABSTRACT
Systemic Lupus Erythematosus (SLE) is a chronic, potentially debilitating, autoimmune condition that mostly
impacts Black women in the United States. Black women with SLE also experience poor outcomes however,
the etiology of SLE and its progression are not well understood. Psychosocial mechanisms have been
proposed as explaining some of the adverse outcomes among Black women with SLE, although most studies
have focused on negative factors, and less is known about protective psychosocial factors. To address these
absent areas in research, the trainee (Khadijah Abdallah) will utilize previously collected data from the Vascular
Aging, Inflammation, and Stress in African-American Women’s Health research Study (VISTA (PI: Lewis;
R01AR070898)) cohort to examine both the latent as well as composite properties of seven positive
psychosocial factors (mastery, purpose in life, religious dimensions, social support, and self-compassion),
their longitudinal impact on cardiovascular (CVD) and renal risk, and the mechanistic pathways, such as
inflammation, that leads to these CVD and renal outcomes. The study also proposes to complement the
quantitative aims through innovative data mining/scraping techniques, such as natural language processing
(NLP) of online forums, to qualitatively assess the socio-cultural context and experiences that shape current
perspectives on psychosocial well-being, allowing for a more nuanced understanding of these phenotypes. The
specific aims of the study are: (1) Identify psychosocial phenotypes using latent profile analysis with positive
psychosocial factors (PPF); (1a) Utilize NLP to collect qualitative data from Black women with and without SLE
on Reddit (a social media platform) to uncover nuanced perspectives and insights into their psychosocial well-
being; (2) Examine the longitudinal impact of PPF on CVD and renal outcomes using a repeated measures
design; (3) Investigate the association between PPF and inflammatory markers associated with CVD and renal
function; (3a) Explore the potential mediating role of inflammatory pathways between PPF and health
outcomes. The expected results of this study are important for understanding risks and protective factors for
chronic disease management and will also enhance knowledge on potential interventions to meet the needs of
these populations living with a debilitating chronic condition. This F31 will also support Ms. Abdallah’s training
in methods, SLE, and health informatics. Ms. Abdallah has assembled a strong team of mentors and
collaborators, many of whom she has collaborated with previously. This includes Dr. Lewis (primary sponsor),
Dr. Lim (collaborator), Dr. Vaccarino (collaborator), Dr. Haardörfer (collaborator), Dr. McGee (collaborator), and
Dr. Sarker (collaborator). They will provide guidance throughout the training period across these topics. Ms.
Abdallah will also benefit from the resources with the doctoral program and the broader community.
Istituzione: EMORY UNIVERSITY
PI: Khadijah Abdallah
Progetto: 1F31AR086007-01A1
Settori: National Institute of Arthritis and Musculoskeletal and Skin Diseases
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