[K23] Administrative Supplement to: Applying digital phenotypes and epigenetics to understand clinical outcomes in acute hypoxemic respiratory failure without acute respiratory distress syndrome (NAHRF)
Ente: National Heart Lung and Blood Institute
Scadenza: 2027-08-14
Importo max: 75.600 EUR
Paese: US
Descrizione
PROJECT SUMMARY
This administrative supplement application requests $70,000 in direct costs for 12 months to sustain
progress on my NHLBI-funded K23 project during a qualifying critical life event (childbirth). The parent K23
applies (1) EHR-derived prediction modeling, (2) machine learning subphenotyping, and (3) whole
methylome profiling to study the clinical and biological heterogeneity driving divergent clinical outcomes in
non-ARDS acute hypoxemic respiratory failure (NAHRF). The project ultimately aims to advance
management of critically ill adults with NAHRF toward precision-based approaches informed by biologic
mechanism. The supplement will support additional personnel to preserve key project operations during and
after a temporary reduction in my research effort; this will ensure continuity of retrospective data processing
and prospective screening and enrollment activities. The anticipated outcome is uninterrupted momentum
toward parent-award milestones, which will facilitate timely completion of the K23 specific aims and support
my progression to research independence.
Istituzione: UNIVERSITY OF CALIFORNIA AT DAVIS
PI: Cosby Arnold
Progetto: 3K23HL177334-02S1
Settori: National Heart Lung and Blood Institute
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