[K23] Developing a daily life measure of depression for persons with aphasia and examining its relation with communicative confidence
Ente: National Institute on Deafness and Other Communication Disorders
Scadenza: 2027-11-30
Importo max: 23.755 EUR
Paese: US
Descrizione
Aphasia is a multi-modality disturbance of language that is often acquired after a left hemisphere stroke. Post-
stroke depression is two times higher in persons with aphasia (PWAs) than in the general stroke population.
Post-stroke depression is associated with worse language and cognitive performance and overall decreased
quality of life. However, PWAs are typically excluded from studies of post-stroke depression due to a lack of valid
assessment tools. More importantly, studies of depression in PWAs only assess depression using weekly
retrospective measures thus ignoring the day-to-day variability in mood. An innovative approach to assessing
the dynamic nature of depression is ecological momentary assessment (EMA). EMAs involve repeated sampling
of data over time in the real-time in real-world environments. EMAs are brief thus minimizing response burden
and are typically collected using mobile phones which are owned by more than 85% of Americans. EMAs are
ecologically valid but have not been used in PWAs due to their language disturbances. A goal of this study is to
use user-centered design to create and validate an aphasia-friendly EMA of depression and investigate its
association with communicative confidence (N = 95). Having the confidence to communicate despite aphasia is
a robust predictor of overall quality of life. Aim 1 of the study will adapt a user-centered design by involving
PWAs, their caregivers, and speech-language pathologists to design and construct brief (~less than 60s) EMA
measure of depression. Validity of the EMA measure will be established using a convergent validity approach
and use as its validator an established depression scale for PWAs. Aim 2 will establish the validity of the EMA
assessment of depression using a smartphone-based measure of physical activity (i.e., step count). Reduced
physical activity is a robust correlate of depression in both neurologically healthy individuals and those with
stroke. Aim 3 will investigate the relationship between depression and communicative confidence and test the
incremental validity of the EMA measure over the retrospective weekly measure of depression. Usability and
feasibility of the EMA will also be established. Lastly, an exploratory aim will determine the association between
smartphone-based physical activity and communicative confidence. The proposed career development award
aims to provide Dr. Ashaie with training activities that will increase his knowledge of (1) psychopathology
especially depression, (2) user-centered design, (3) EMA methods, and (4) analyzing smartphone-based sensor
data. The training goals will be accomplished through mentored training, formal coursework, and seminars and
workshops. His interdisciplinary mentorship team consists of leading experts in depression and transdiagnostic
research (Dr. Shankman), user-centered design (Dr. Reddy), designing depression assessments (Dr. Griffith),
statistics (Dr. Siddique), and analyzing passive smartphone-ba
Istituzione: REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB
PI: Sameer Afzal Ashaie
Progetto: 3K23DC020757-04S1
Settori: National Institute on Deafness and Other Communication Disorders
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