[R01] Optimal physical activity timing and 24-hour activity composition for prevention of hypertensive disorders of pregnancy
Ente: National Heart Lung and Blood Institute
Scadenza: 2030-06-30
Importo max: 719.315 EUR
Paese: US
Descrizione
Modified Project Summary/Abstract Section
De novo hypertensive disorders of pregnancy (HDP), including gestational hypertension and
preeclampsia/eclampsia, impact 10-15% of pregnancies and are considered salient risk factors
for future cardiovascular disease (CVD) in women. Moderate-to-vigorous physical activity (PA) is
strongly recommended for CVD prevention; however, there is currently limited evidence on the
importance of PA timing (early vs. mid-pregnancy and change across pregnancy) for HDP
prevention. In addition, light-intensity PA has been linked to better cardiovascular risk profiles in
the general adult population, but few studies have investigated associations of light-intensity PA
during pregnancy with HDP, when light-intensity PA may be a more achievable behavior and
associations may differ due to pregnancy-associated cardiovascular changes. Finally, previous
research in the general adult population suggests the composition of the entire 24-hour day—
which includes sleep and sedentary behavior in addition to PA—impacts CVD risk and mortality;
however, the optimal 24-hour activity composition for reducing risk of HDP remains unclear as
few studies have considered more than one behavior simultaneously. As behaviors are not
independent within the context of the 24-hour day, applying a 24-hour activity paradigm, including
sleep, sedentary behavior, light-intensity PA, and moderate-to-vigorous-intensity PA, is important
for understanding these relationships. Identifying beneficial lifestyle-related behaviors and
combinations of these behaviors to reduce risk of HDP is of critical importance to inform the
development of clinical and public health guidelines and to promote lifestyle strategies to reduce
CVD risk in women. To address this critical gap, the proposed study will explore PA timing and
intensity and optimal 24-hour activity compositions at multiple pregnancy timepoints for reducing
HDP risk. We will leverage Kaiser Permanente Northern California’s diverse population of
pregnant women and extensive electronic health record database, along with innovative 24-hour
accelerometry, to conduct a longitudinal cohort study of 1,050 pregnant women with follow-up
from early pregnancy through delivery. In early and mid-pregnancy, we will collect devicemeasured 24-hour activity creating a large cohort with measurement of multiple aspects of PA
and sleep across pregnancy linked to de novo HDP identified by validated algorithms in the
electronic health record to determine prospective associations of PA in pregnancy by timing and
intensity (Aim 1) and identify optimal 24-hour activity compositions (Aim 2) with risk of HDP, and
explore mediators and moderators of these associations (Exploratory Aim). Results will elucidate
the relationships between PA timing and intensities, and optimal 24-hour activity paradigm, and
risk of HDP. These findings will be paramount for guiding future PA and 24-hour activity
guidelines for pregnancy and clinical tria
Istituzione: KAISER FOUNDATION RESEARCH INSTITUTE
PI: Sylvia E Badon
Progetto: 5R01HL176879-02
Settori: National Heart Lung and Blood Institute
Vai al bando originale
Registrati gratis su Bandolo per trovare bandi compatibili con la tua azienda.