[R35] Lipid functions in bacterial cell organization
Ente: National Institute of General Medical Sciences
Scadenza: 2027-07-31
Importo max: 385.000 EUR
Paese: US
Descrizione
Title:
Lipid functions in bacterial membrane organization
Project Abstract: Cellular membranes can be organized by the formation of discrete membrane
microdomains (MMs), such as the cholesterol- and flotillin-rich “lipid rafts” found in eukaryotes. In
bacteria, little is understood about the spatial organization of the cell membrane. Because this
domain does not synthesize cholesterol or related eukaryotic lipids, it traditionally has been
assumed that they do not contain raft-like compartments. Hopanoid lipids are the closest bacterial
analogs of cholesterol, and my lab has found that they promote formation of MMs in the facultative
endosymbiont Bradyrhizobium diazoefficiens. In this award, we are pursuing two independent
projects. In Project 1, we will assess whether hopanoid-mediated MMs are homologous to
eukaryotic lipid rafts and identify biological processes that are coordinated in these regions. In
Project 2, we will examine the relative contributions of inner vs. outer membrane hopanoids to B.
diazoefficiens to membrane biophysics, stress sensitivity, and cellular organization.
Istituzione: UNIVERSITY OF KENTUCKY
PI: Brittany Jo Belin
Progetto: 7R35GM147015-05
Settori: National Institute of General Medical Sciences
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