[Studentship] Investigating the Regulation and Replication of R-loops at Telomeres

Ente: Medical Research Council

Scadenza: 2028-10-05

Paese: GB

Descrizione

Eukaryotic chromosomes are capped at each end by specialised nucleoprotein structures called telomeres, which are mutated or altered in essentially all incidences of cancer. Telomeres are transcribed into a non-coding RNA called TERRA, which forms a three-stranded R-loop structure in which the RNA remains bound to the template. R-loops are particularly prevalent at telomeres in ALT-type cancer cells, where they are thought to prevent efficient replication of the chromosome end. This project will identify novel R-loop regulating factors at telomeres and examine how TERRA-based R-loops regulate and influence the telomere replication process.

Settori: Division of Cancer Biology

Vai al bando originale

Registrati gratis su Bandolo per trovare bandi compatibili con la tua azienda.