[CoSMOS-BC] Co-culture System with Microfluidics and Onboard Sensors for Breast Cancer study
Ente: EC
Scadenza: 2028-08-31
Importo max: 209.915 EUR
Paese: EU
Descrizione
Breast cancer (BC) remains one of the leading causes of cancer-related deaths among women worldwide, with incidence rates rising and a significant economic burden. The disease is characterized by its dynamic and heterogeneous nature, involving complex molecular, genetic, and cellular changes.
The tumor microenvironment (TME), particularly its inflammatory components such as cytokines, plays a crucial role in BC progression and treatment response. While targeted therapies have improved outcomes for some BC subtypes, significant challenges persist especially in treating triple-negative breast cancer (TNBC), which lacks specific molecular targets. The development of microfluidics devices that enable precise spatiotemporal control in cell culture offers new opportunities to simulate and study the TME more effectively than conventional methods. Such devices are crucial for modeling cancer progression and deepening our understanding of its biology. By mimicking human physiology, they provide a controlled platform for testing new therapies, reducing animal testing, and accelerating drug development. Additionally, they facilitate personalized medicine by recreating patient-specific tumor microenvironments and supporting tailored treatments. These advancements also bridge the gap between in vitro studies and clinical applications, driving oncology research forward and offering hope to millions of people. Aiming this, CoSMOS-BC proposes a microfluidic co-culture system with integrated sensors for real-time cytokine detection at the cellular level, designed to provide insights into intercellular communication and understand cellular dynamics within the TME. CoSMOS-BC has the potential to make significant strides in both the diagnosis and personalized treatment of breast cancer, paving the way for more effective and targeted therapeutic strategies.
Settori: Horizon Europe Topics
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