[K23] TARGET-VIPeR: Testing And Response in Guideline-Engaged Treatment of Viral Respiratory Infections in Pediatric High-Risk Patients
Ente: National Institute of Allergy and Infectious Diseases
Scadenza: 2031-07-31
Importo max: 194.400 EUR
Paese: US
Descrizione
PROJECT SUMMARY/ABSTRACT
Candidate: Dr. Claire Abraham is a practicing pediatrician in the Division of General Pediatrics at Boston
Children’s Hospital (BCH). She completed her pediatrics residency at NewYork-Presbyterian/Columbia
University, and General Academic Pediatrics and T32-funded pediatric health services research fellowships at
BCH. Building on her prior influenza research, this proposal focuses on three critical areas of career
development: electronic health records derived data analytic skills, decision science methodologic training, and
experience in the design, implementation, and evaluation of a health system intervention pilot. This will be
accomplished through formal coursework, collaborative research, attendance at conferences, and guidance
from a unique group of mentors. The research and training plan builds the foundation for an independent
research career that aims to develop, test, and spread health system interventions to increase guideline
concordant testing and treatment of pediatric respiratory illness in the outpatient setting.
Research: Children under age 5 years and those with comorbid medical conditions are at particularly high risk
for influenza related complications. National guidelines recommend treatment with oseltamivir for high-risk
patients with influenza as soon as possible, regardless of duration of symptoms. Despite these
recommendations, fewer than 40% of pediatric patients at high risk of influenza complications received
guideline concordant antiviral treatment. This study will provide novel information on the association between
influenza testing and oseltamivir treatment and the perceived parental and health care provider drivers of
testing and treatment that can be addressed through health system interventions. This proposal details a five-
year plan to provide the training and expertise required to achieve the following specific aims: 1) address gaps
in characterizing influenza testing and treatment practices, 2) assess perceived facilitators and barriers to
recommended testing and treatment, and 3) develop and pilot a health system intervention to promote
guideline concordant care. At the end of this project, Dr. Abraham will be well positioned to apply for an R01 to
further evaluate the effectiveness of this intervention.
Environment: Dr. Abraham is supported by outstanding mentorship provided by experts in quality of care
intervention development, testing, and evaluation (Kathleen E. Walsh, MD, MS), interventions to improve
health knowledge and motivate positive health behaviors related to influenza (Melissa Stockwell, MD, MPH),
and decision science methodology (Davene Wright, PhD). These mentors have committed their time,
resources, and expertise to facilitate her career development and successful completion of the proposed
project. The educational opportunities and research support at BCH and HMS provides an ideal training
environment in which to achieve research independence.
Istituzione: BOSTON CHILDREN'S HOSPITAL
PI: Claire Abraham
Progetto: 1K23AI202237-01
Settori: National Institute of Allergy and Infectious Diseases
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