[R01] General Capillary to Arterial Endothelial Cell Transition in Pulmonary ArterialHypertension
Ente: National Heart Lung and Blood Institute
Scadenza: 2027-06-30
Importo max: 709.341 EUR
Paese: US
Descrizione
Project Summary
Pulmonary arterial hypertension (PAH) is characterized by a progressive increase of pulmonary
vascular resistance and obliterative pulmonary vascular remodeling that result in right heart hypertrophy,
failure, and premature death. The underlying mechanisms of loss of capillary endothelial cells (ECs) and
obliterative vascular lesion formation remain unclear. Our preliminary data showed that arterial
programing was evident in human PAH patients and rodents. We hypothesize that general capillary ECs
program to arterial ECs through HIF-2α-Cdk19/Sox17/Notch4 signaling which contributes to the
pathogenesis of PAH. Completing our proposed study will provide a novel therapeutic strategy for the
effective treatment of PAH in patients.
Istituzione: WASHINGTON UNIVERSITY
PI: Zhiyu Dai
Progetto: 5R01HL170096-04
Settori: National Heart Lung and Blood Institute
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