[ULTRA Plants] Unlocking Latent Totipotency for Regeneration Advancement in Plants
Ente: EC
Scadenza: 2029-03-31
Importo max: 200.400 EUR
Paese: EU
Descrizione
Regeneration is a vital survival strategy that enables injured plants to recover from damage, and it is an indispensable tool in agriculture for efficient propagation. This remarkable capacity relies on extraordinary developmental plasticity, allowing plants to regenerate tissues and organs through wound-induced pathways. However, little is known about how wounding triggers plant regeneration, creating a fundamental bottleneck for both basic science and applied innovation.
The “ULTRA Plants” project tackles this challenge by addressing a bold question: how do plants perceive wound signals to activate downstream cascades driving regeneration? Proof-of-concept data suggest that HEAT SHOCK FACTOR A1s (HSFA1s), the master regulators of stress responses, rapidly translocate into the nucleus upon wounding and promote regeneration. I therefore hypothesize that wound-induced HSFA1s play a key role in transmitting wound signals to trigger plant regeneration.
To test this theory, I will (I) identify signaling molecules and their receptors upstream of HSFA1s via pharmacological screening, (II) dissect regulatory mechanisms driving HSFA1 nuclear translocation through forward genetics, and (III) map HSFA1-centered transcriptional dynamics at single-cell resolution using state-of-the-art spatial transcriptomics. These results will establish a new framework for understanding wound signals and provide innovative strategies to improve plant regeneration.
Building on the exciting preliminary data, I will integrate cutting-edge technologies with leading expertise of my host lab to transform our view of plant developmental plasticity and unlock regeneration potential in recalcitrant plants. On a personal level, this fellowship will provide me with advanced training in genetics, systems biology, computational approaches, together with structured career development, thereby equipping me to independently lead innovative research at the interface of plant development and biotechnology.
Settori: Horizon Europe Topics
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