[R01] 2/3 Akili: Phenotypic and genetic characterization of ADHD in Kenya and South Africa
Ente: National Institute of Mental Health
Scadenza: 2028-05-31
Importo max: 498.881 EUR
Paese: US
Descrizione
PROJECT SUMMARY
ADHD is a common neurodevelopmental disorder that includes attention difficulty, impulsivity, and hyperactivity. The diagnosis is associated with many challenges to educational, occupational, and health outcomes, particularly when untreated. Genetic studies of ADHD have the potential to clarify the disorder’s biological underpinnings, its heterogeneity, and its relationship to other neuropsychiatric diagnoses. However, genetic research into ADHD lags in terms of both sample size and considerations of phenotypic heterogeneity. Akili is designed to address both of these critical gaps. Akili (the Swahili term for “mind”) will enroll 6,000 children in Kenya and South Africa – 4,000 with a confirmed diagnosis of ADHD and 2,000 age- and ancestry-matched controls. All participants will complete a detailed behavioral, cognitive, and medical phenotyping battery, and provide a DNA sample. We will genetically characterize all 6,000 participants using exome sequencing and genome-wide genotyping, and make all Akili data and materials publicly available through the NIMH. Akili data will nearly double the number of ADHD cases available for exome sequencing analysis and provide a 20% addition to the current PGC-ADHD GWAS activity. Akili will generate a research resource of international value. Akili will unite genetic sequencing with deep clinical phenotyping expertise to improve biological understanding of ADHD, a common and impactful diagnosis for families in the United States; and will also introduce genomic data currently missing from reference databases, directly advancing genetic diagnostic accuracy and precision medicine for all U.S. demographic groups.
Istituzione: AGA KHAN UNIVERSITY (KENYA)
PI: Amina Abubakar Ali
Progetto: 5R01MH132965-04
Settori: National Institute of Mental Health
Vai al bando originale
Registrati gratis su Bandolo per trovare bandi compatibili con la tua azienda.