[R01] Modularly Defined Stilbenoids as Functional Dental Biopolymers

Ente: National Institute of Dental and Craniofacial Research

Scadenza: 2031-06-30

Importo max: $601,409

Paese: US

Descrizione

Summary The direct resin composite restoration is the most widely used and conservative approach for treating dental caries, but has a relatively high failure rate, primarily caused by the development of secondary caries around these restorations. As ~50% of resin composite restorations are replacements of failing fillings, this creates recurring cycles of restorative treatments, escalating complexity, unfavorable tooth prognosis, and rising costs. The underlying key factor is micro-mechanical resin adhesion to both enamel and dentin structures, as the restorations strongly depend on it. Dentin, the major constituent of the tooth, plays a key role in this process, and components of dentin’s extracellular matrix are essential for the formation and durability of the dentin-resin bonds. Inspired by the native properties of dentin, our interdisciplinary team has discovered a new group of plant- derived, renewable phenolic polymers that can mimic the natural processes of tissue toughening. This breakthrough led us to pioneer their use as tissue biomodification materials to ultimately enhance the performance of adhesive-based dental restorations. Dentin biomodification is an innovative strategy for improving the strength and stability of the dentin matrix while also enhancing resin-dentin adhesive bonds, yielding more durable resin-tooth interfaces. As we gained deeper insight into the phytochemistry of these biopolymers and their multifunctional dentin interaction mechanisms, our investigations expanded to structurally diverse classes of modular oligomeric phenols. This led to the Modularly Defined Stilbenoids (MoDS) introduced here as a new class of plant-derived biopolymers with promising effects on dentin and dentin-resin interfaces. Our preliminary work shows that MoDS elicit high dentin biomodification traits, promising biocompatibility with cells and dental resin chemistry, offering a broad, sustainable impact in the field of restorative/reparative dentistry. Our core hypotheses are: (h1) Modularity, molecular size (degree of polymerization) and shape (specific stereochemistry) engender the structural uniqueness of MoDS as dentin-effective and tailorable biopolymers; (h2) MoDS-based and biocompatible Functional Adhesive Biomaterials Systems (FABS) mediate long-lasting dentin modification/modulation that will outperform existing materials. The trans-disciplinary study design involves three Specific Aims: (Aim 1) Generate structurally diverse and rigorously characterized natural MoDS and bio-inspired analogues, fit for establishing structure-activity relationship (SAR) knowledge required to develop functional dental biomaterials. (Aim 2) Establish the SARs of MoDS by defining their short and long term interactions with dentin, and assess key biocompatibility parameters with cells and dental resins. (Aim 3) Develop and assess chemically and biologically standardized MoDS-based FABS and assess their performance under clinically relevant conditions a Istituzione: UNIVERSITY OF ILLINOIS AT CHICAGO PI: Ana Karina B Bedran-Russo, Guido F Pauli Progetto: 1R01DE035529-01A1

Settori: National Institute of Dental and Craniofacial Research

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